期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 33, 期 7, 页码 1968-1977出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/eji.200323831
关键词
IL-7 receptor; pre-TCR; proliferation; survival
类别
The pre-T cell receptor (pre-TCR) and IL-7 receptor (IL-7R) are critical mediators of survival, proliferation and differentiation in immature thymocytes. Here we show that pre-TCR signaling directly maintains IL-7alpha expression as developing thymocytes undergo beta-selection. Inhibition of IL-7/IL-7R signaling in (CD44(-)CD25(-)) DN4 cells results in decreased generation of double-positive thymocytes due to increased death of rapidly proliferating P-selected cells. Thus, we identify a mechanism by which pre-TCR signaling controls the selective survival of TCRbeta(+) thymocytes, and define a further stage of T cell differentiation in which signaling from a TCR regulates the ability of that cell to respond to cytokine.
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