期刊
AIDS RESEARCH AND HUMAN RETROVIRUSES
卷 19, 期 7, 页码 535-541出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/088922203322230897
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资金
- NCRR NIH HHS [RR-00166] Funding Source: Medline
- NIAID NIH HHS [AI-15450, AI-65311] Funding Source: Medline
Cyanovirin-N (CV-N), an 11-kDa cyanobacterial protein, potently inactivates diverse strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) and also prevents virus-to-cell fusion, virus entry, and infection of cells in vitro. These properties make CV-N an attractive candidate for use as a topical microbicide to prevent the sexual transmission of HIV. We evaluated the efficacy of gel-formulated, recombinant CV-N gel as a topical microbicide in male macaques (Macaca fascicularis) that were rectally challenged with a chimeric SIV/HIV-1 virus known as SHIV89.6P. All of the untreated macaques were infected and experienced CD4(+) T cell depletion. In contrast, none of the macaques that received either 1 % or 2 % CV-N gel showed evidence of SHIV89.6P infection. Neither CV-N nor placebo gels produced Any adverse effects in any macaque following the rectal application. These results indicate that CV-N gel As a topical microbicide can prevent rectal transmission of SHIV in macaques. These studies encouraged clinical evaluation of CV-N as a topical microbicide to prevent sexual transmisision of HIV in humans.
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