期刊
INFECTION AND IMMUNITY
卷 71, 期 7, 页码 3954-3959出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.71.7.3954-3959.2003
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资金
- NIAID NIH HHS [AI-08649, AI-40644] Funding Source: Medline
The gerH(ABC) operon of Bacillus anthracis, encoding a gerA-like family member of germinant sensors, was shown to be required for endospore germination in the presence of macrophages and in macrophage-conditioned media. The loss of the germination phenotype in macrophage cultures of B. anthracis gerH-null endospores was restored by complementation in trans with a wild-type copy of gerH expressed under the control of its own promoter. Using endospores from both the parental strain B. anthracis Sterne and an isogenic gerH-null strain, we partially characterized germinants secreted by macrophages into the extracellular medium.
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