期刊
NATURE REVIEWS DRUG DISCOVERY
卷 2, 期 7, 页码 587-593出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd1133
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The large-scale commercial production of a 36-amino-acid peptide by chemical synthesis has been demonstrated in the development of enfuvirtide (T-20 or Fuzeon), a first-in-class membrane fusion inhibitor for the treatment of HIV. The rationale behind route selection and the scale-up of the process used to manufacture enfuvirtide are discussed.
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