期刊
JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT
卷 40, 期 4, 页码 55-62出版社
JOURNAL REHAB RES & DEV
DOI: 10.1682/JRRD.2003.08.0055
关键词
central nervous system (CNS) regeneration; contusion injury; cyclic adenosine monophosphate; methylprednisolone; neurotrophins; olfactory ensheathing glia; raphespinal tract; Schwann cells; spinal cord transection
资金
- PHS HHS [38665, N09923] Funding Source: Medline
This review describes the results of the transplantation of Schwann cells and olfactory ensheathing glia in combination with other interventions. The complete transection injury model was used to test the combination of Schwann cell bridges with methylprednisolone, neurotrophins, or olfactory ensheathing glia. The contusion injury model was used to compare Schwann cell and olfactory ensheathing glia transplantation and to examine the results of combining Schwann cell transplants with elevated levels of cyclic adenosine monophosphate. The combination strategies were more effective than cell transplantation alone. The improved regeneration response usually involved a reduction in secondary tissue loss, axonal regeneration from brainstem neurons, an increase in myelinated fibers in the transplant, the exit of regenerated fibers from the transplant into the contiguous cord, and an improvement in locomotor function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据