期刊
MAGNETIC RESONANCE IN MEDICINE
卷 50, 期 1, 页码 201-205出版社
WILEY
DOI: 10.1002/mrm.10511
关键词
MR microscopy; transplantation; iron oxide MR contrast agent; neurospheres; experimental autoimmune encephalomyelitis
资金
- NINDS NIH HHS [R01 NS45062] Funding Source: Medline
Stem cell transplantation is being explored as a new paradigm for the treatment of demyelinating diseases. Magnetically labeled multipotential neural precursor cells were transplanted into the ventricles of rats with acute experimental allergic encephalomyelitis (EAE) and high-resolution (microscopic) MR images were obtained ex vivo. Migration patterns of live cells into periventricular white matter structures could be easily visualized, with a good correlation of the corresponding histopathology. The present results confirm that MR cell tracking can be used to guide the development of successful transplantation protocols. (C) 2003 Wiley-Liss, Inc.
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