期刊
ARCHIVES OF VIROLOGY
卷 155, 期 7, 页码 1145-1150出版社
SPRINGER WIEN
DOI: 10.1007/s00705-010-0676-2
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- State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology
- University of Hong Kong, Pokfulam, Hong Kong SAR, China
- Li Ka Shing Faculty of Medicine
- Southeast Poultry Research Laboratory US Department of Agriculture, Athens, Georgia
- Russian Government [BII ISTC 3436]
Three viruses included in the study were isolated from dead birds (A/duck/Omsk/1822/2006, A/chicken/Reshoty/02/2006, and A/duck/Tuva/01/2006), whereas the virus A/common gull/Chany/P/2006 was isolated from an apparently healthy gull during outbreaks of highly pathogenic avian influenza in Russia in 2006. The intravenous pathogenicity index (IVPI) of viruses A/duck/Omsk/1822/2006, A/chicken/Reshoty/02/2006, and A/duck/Tuva/01/2006 ranged from 2.7 to 3.0, while the virus A/common gull/Chany/P/2006 had a markedly lower IVPI of 1.7. The virus A/common gull/Chany/P/2006 had a unique pattern of six amino acid substitutions in the regions of viral proteins crucial for virulence of H5N1 viruses. We hypothesize that these substitutions may affect the pathogenicity of A/common gull/Chany/P/2006.
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