期刊
TETRAHEDRON
卷 59, 期 28, 页码 5307-5315出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(03)00762-2
关键词
peptides; Celosia argentea; tubulin polymerization
Six new bicyclic peptides, celogentins D-H (1-5) and J (6) have been isolated from the seeds of Celosia argentea, and the structures including its absolute stereochemistry were determined by using extensive NMR methods and chemical means. Celogentins E-H (2-5) and J (6) showed potent inhibition of tubulin polymerization, while the inhibitory activity of celogentin D (1) was modest. Structure-activity relationship study indicates that ring size of the bicyclic ring system including unusual (beta(s)-Leu, Trp, and His residues would be important for their biological activity. (C) 2003 Elsevier Science Ltd. All rights reserved.
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