期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 13, 期 13, 页码 2109-2112出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(03)00376-7
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We previously demonstrated that piperazinyl-linked fluoroquinolone dimers possess potent antibacterial activity against drug-resistant strains of Staphylococcus aureus. In this study, we report the preparation and evaluation of a series of incomplete dimers toward ascertaining structural features of piperazinyl-linked ciprofloxacin dimers that render these agents refractory to fluoroquinolone-resistance mechanisms in Staphylococcus aureus. (C) 2003 Elsevier Science Ltd. All rights reserved.
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