期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 198, 期 1, 页码 79-89出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20021548
关键词
Stat5; TCR; lymphoma; DNA microarray; CD8(+)T cell
Signal transducer and activator of transcription (STAT) proteins are latent transcription factors that mediate a wide range of actions induced by cytokines, interferons, and growth factors. We now report the development of thymic T cell lymphoblastic lymphomas in transgenic mice in which Stat5a or Stat5b is overexpressed within the lymphoid compartment. The rate of lymphoma induction was markedly enhanced by immunization or by the introduction of TCR transgenes. Remarkably, the Stat5 transgene potently induced development of CD8(+) T cells, even in mice expressing a class II-restricted TCR transgene, with resulting CD8(+) T cell lymphomas. These data demonstrate the oncogenic potential of dysregulated expression of a STAT protein that is not constitutively activated, and that TCR stimulation can contribute to this process.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据