期刊
ARCHIVES OF VIROLOGY
卷 153, 期 7, 页码 1391-1396出版社
SPRINGER WIEN
DOI: 10.1007/s00705-008-0129-3
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资金
- NIAID NIH HHS [1R01AI063513-01A2, U54 AI057156, T32 AI007536] Funding Source: Medline
Pichinde virus (PICV) is a New World arenavirus that has been shown to enter cells through a clathrin-dependent endocytic pathway. In this study, we determined that PICV is trafficked through the cellular dynamin 2 (dyn2) endocytic pathway. Additionally, the data suggest that PICV entry is pH-dependent and that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes. In all, this study characterizes the endocytic pathway utilized by the arenavirus PICV.
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