期刊
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
卷 37, 期 2-3, 页码 129-134出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0928-8244(03)00067-1
关键词
immunodeficiency virus; Shigella; vaccine vector; mucosal immunity; Salmonella
资金
- NIAID NIH HHS [AI47490, AI43756, AI41914] Funding Source: Medline
Conformationally constrained HIV-1 Env and gp120 immunogens induce broadly cross-reactive neutralizing antibodies. Thus, it is now feasible to rationally design an HIV-1 vaccine that affords protection through humoral mechanisms. This paper reviews our progress toward the development of an oral bacterial vaccine vector that is capable of delivering an HIV-1 DNA vaccine to host lymphoid tissues and inducing broadly neutralizing antibodies to HIV-1 in the mucosal and systemic immune compartments. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
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