期刊
JOURNAL OF IMMUNOLOGY
卷 171, 期 2, 页码 655-663出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.171.2.655
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- NCI NIH HHS [CA-34461] Funding Source: Medline
- NIAID NIH HHS [AI-17672] Funding Source: Medline
- NIAMS NIH HHS [AR-35506] Funding Source: Medline
- NIDDK NIH HHS [DK32520] Funding Source: Medline
Viruses can cause a severe lymphopenia early in infection and a subsequent, lasting loss of pre-existing CD8(+) memory T cells. We therefore questioned how well virus Ag-specific memory CD8(+) T cells could reconstitute mice rendered lymphopenic as a consequence of genetics, irradiation, or viral or poly(I:C)-induced cytokines. In each case, reconstitution of the CD8(+) compartment was associated with limited division of virus-specific memory T cells and a reduction in their proportion. This indicates that foreign Ag-experienced CD44(high)CD8(+) memory T cells may respond differently to homeostatic signals than other CD44(high)CD8(+) cells, and that events inducing lymphopenia may lead to a permanent reduction in T cell memory.
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