(S)-N-[1-(3-Morpholin-4-ylphenyl)ethyl]-3phenylacrylamide:: An orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine

(S)-N-[1-(3-Morpholin-4-ylphenyl)ethyl]-3-phenyl-acrylamide (2) was synthesized as an orally bioavailable KCNQ2 potassium channel opener. In a rat model of migraine, 2 demonstrated significant oral activity in reducing the total number of cortical spreading depressions induced by potassium chloride.