Treatment with dihydroethidium reduces infarct size after transient focal cerebral ischemia in mice

A transient focal ischemia model with C57B1/6 mice was used to investigate whether dihydroethidium is neuroprotective. Different doses (25, 50, 100 mg/kg body weight) were used for pretreatment and the lowest effective dose was used for delayed treatment 1 and 2 h after reperfusion. Our results demonstrate that all the doses used for treatment reduced infarct volume. We conclude that dihydroethidium is neuroprotective by reducing superoxide in mice after stroke. (C) 2003 Elsevier Science B.V. All rights reserved.