期刊
BRAIN RESEARCH
卷 978, 期 1-2, 页码 223-227出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(03)02775-6
关键词
delayed treatment; dihydroethidium; focal cerebral ischemia; neuroprotection; stroke; superoxide anion
资金
- NINDS NIH HHS [R01 NS38653, R01 NS36147, R01 NS25372, P50 NS14543] Funding Source: Medline
A transient focal ischemia model with C57B1/6 mice was used to investigate whether dihydroethidium is neuroprotective. Different doses (25, 50, 100 mg/kg body weight) were used for pretreatment and the lowest effective dose was used for delayed treatment 1 and 2 h after reperfusion. Our results demonstrate that all the doses used for treatment reduced infarct volume. We conclude that dihydroethidium is neuroprotective by reducing superoxide in mice after stroke. (C) 2003 Elsevier Science B.V. All rights reserved.
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