期刊
CANCER LETTERS
卷 197, 期 1-2, 页码 145-150出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3835(03)00095-8
关键词
neuroblastoma; hypoxia; hypoxia inducible factors; sympathetic nervous system; neural crest; catecholamine synthesis; differentiation; dedifferentiation
类别
Hypoxia in solid tumors is associated with aggressive behavior and poor outcome. We recently discovered that hypoxia alters the expression of differentiation marker genes in neuroblastoma cells, in that the tumor cells adjust to the hypoxic environment by down-regulating genes associated with a neuronal and upregulating genes associated with a neural crest-like phenotype. As there is a correlation in neuroblastoma between low stage of differentiation and high (aggressive) clinical stage, we propose that dedifferentiation of neuroblastoma cells in hypoxic tumor regions contribute to the malignancy of the tumor. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据