期刊
TETRAHEDRON
卷 59, 期 30, 页码 5667-5675出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(03)00908-6
关键词
Lewis acid; Lewis base; catalyst; cyanosilylation; ketone
A new family of bifunctional catalysts (N-oxides-Ti((OPr)-Pr-i)(4) (2: 1)) containing a Lewis acid and a Lewis base was developed and applied to the catalytic cyanosilylation of ketones. Utilizing rac((1R,2S) and (1S,2R))-1-(2'-pyridylmethyl)-2-diphenylhydroxymethylpyrrolidine N-oxide-titanium (2: 1) complex and N-benzyl-diethanolamine N-oxide-titanium (2: 1) complex as catalysts, the cyanosilylation products were obtained in 42-97% yield. Based on experimental phenomena and kinetic studies, a catalytic cycle was proposed to explain the remarkable activities of these catalysts. Investigations indicated that rac((1R,2S) and (1S,2R))-1-(2'-pyridylmethyl)-2-diphenylhydroxy-methylpyrrolidine N-oxide-titanium (2:1) complex and N-benzyl-diethanolamine N-oxide-titanium (2:1) complex should promote the reaction via a dual activation of the ketone by the titanium and TMSCN by the N-oxide. (C) 2003 Elsevier Ltd. All rights reserved.
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