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FREE RADICAL BIOLOGY AND MEDICINE (2005)
Nuclear oncoprotein prothymosin α is a partner of Keap1:: Implications for expression of oxidative stress-protecting genes
RN Karapetian et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Gene expression profiling of NRF2-mediated protection against oxidative injury
HY Cho et al.
FREE RADICAL BIOLOGY AND MEDICINE (2005)
Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome
Y Katoh et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2005)
Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription
MJ Calkins et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Purification, crystallization and preliminary X-ray diffraction analysis of the Kelch-like motif region of mouse Keap1
B Padmanabhan et al.
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2005)
BTB protein keap1 targets antioxidant transcription factor nrf2 for ubiquitination by the cullin 3-Roc1 ligase
M Furukawa et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Stimulus-specific differences in protein kinase Cδ localization and activation mechanisms in cardiomyocytes
VO Rybin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Control of the SCFSkp2-Cks1 ubiquitin ligase by the APC/CCdh1 ubiquitin ligase
T Bashir et al.
NATURE (2004)
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
W Wei et al.
NATURE (2004)
Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products
AL Levonen et al.
BIOCHEMICAL JOURNAL (2004)
Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes
MI Kang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers
N Wakabayashi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Metallothioneins: Zinc, cadmium, mercury, and copper thiolates and selenolates mimicking protein active site features - Structural aspects and biological implications
G Henkel et al.
CHEMICAL REVIEWS (2004)
The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase
SB Cullinan et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis
K Iida et al.
CANCER RESEARCH (2004)
A novel mechanism of chemoprotection by sulforaphane: Inhibition of histone deacetylase
MC Myzak et al.
CANCER RESEARCH (2004)
Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice
J Li et al.
PHYSIOLOGICAL GENOMICS (2004)
Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C δ
BJ Li et al.
GENES & DEVELOPMENT (2004)
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate for proteasomal degradation of Nrf2
A Kobayashi et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Crystal structure of the Kelch domain of human Keap1
XC Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Nrf3 negatively regulates antioxidant-response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene
K Sankaranarayanan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron
M McMahon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
DD Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice
T Rangasamy et al.
JOURNAL OF CLINICAL INVESTIGATION (2004)
BRCA1 induces antioxidant gene expression and resistance to oxidative stress
I Bae et al.
CANCER RESEARCH (2004)
PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress
SB Cullinan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system
LY Wu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
NAD(P)H:quinone oxidoreductase 1:: Role as a superoxide scavenger
D Siegel et al.
MOLECULAR PHARMACOLOGY (2004)
Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression
DA Bloom et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
ATP-dependent reduction of cysteine-sulphinic acid by S-cerevisiae sulphiredoxin
B Biteau et al.
NATURE (2003)
Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts
A Hayashi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival
SB Cullinan et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase
L Pintard et al.
NATURE (2003)
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3
L Xu et al.
NATURE (2003)
BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases
R Geyer et al.
MOLECULAR CELL (2003)
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs
G Reid et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
SKN-1 links C-elegans mesendodermal specification to a conserved oxidative stress response
JH An et al.
GENES & DEVELOPMENT (2003)
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
M McMahon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles
K Itoh et al.
GENES TO CELLS (2003)
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway - Identification of novel gene clusters for cell survival
MK Kwak et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element - Degradation of Nrf2 by the 26 S proteasome
T Nguyen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones
EC Pietsch et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium
D Stewart et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases
M Furukawa et al.
NATURE CELL BIOLOGY (2003)
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
N Wakabayashi et al.
NATURE GENETICS (2003)
Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
DD Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children
MT Smith et al.
BLOOD (2002)
Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription
HC Huang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme quinone reductase
JQ Gu et al.
JOURNAL OF NATURAL PRODUCTS (2002)
Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQ01
G Asher et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm
LM Zipper et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite
PF Gong et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2002)
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
AT Dinkova-Kostova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system
M Kobayashi et al.
GENES TO CELLS (2002)
Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice
SA Chanas et al.
BIOCHEMICAL JOURNAL (2002)
Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors
H Motohashi et al.
GENE (2002)
Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with promyelocytic leukemia nuclear bodies
A Muto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors
JW Fahey et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate
YS Zhang et al.
BIOCHEMICAL JOURNAL (2002)
Induction of quinone reductase by withanolides
RI Misico et al.
JOURNAL OF NATURAL PRODUCTS (2002)
Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents:: Role of antioxidant response element-like sequences in the nrf2 promoter
MK Kwak et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex
N Zheng et al.
NATURE (2002)
Total intracellular accumulation levels of dietary isothiocyanates determine their activity in elevation of cellular glutathione and induction of Phase 2 detoxification enzymes
LX Ye et al.
CARCINOGENESIS (2001)
Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription
Y Katoh et al.
GENES TO CELLS (2001)
TGF-β signaling in tumor suppression and cancer progression
R Derynck et al.
NATURE GENETICS (2001)
Regulation of the yeast Yap1p nuclear export signal is mediated by redox signal-induced reversible disulfide bond formation
S Kuge et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein - Implication for heme oxygenase-1 gene regulation
CH He et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust
Y Aoki et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2001)
Phosphatidylinositol 3-kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma cells
JM Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Phosphorylation sites of protein kinase C δ in H2O2-treated cells and its activation by tyrosine kinase in vitro
H Konishi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Hemin-induced activation of the thioredoxin gene by Nrf2 - A differential regulation of the antioxidant responsive element by a switch of its binding factors
YC Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Potency of Michael reaction accepters as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
AT Dinkova-Kostova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
M Ramos-Gomez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Transcript leader regions of two Saccharomyces cerevisiae mRNAs contain internal ribosome entry sites that function in living cells
W Zhou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase-1
G Asher et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes
A Enomoto et al.
TOXICOLOGICAL SCIENCES (2001)
The chemical diversity and distribution of glucosinolates and isothiocyanates among plants
JW Fahey et al.
PHYTOCHEMISTRY (2001)
Properties and biological activities of thioredoxins
G Powis et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2001)
Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate
FL Chung et al.
CARCINOGENESIS (2000)
Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2
HC Huang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Suppression of rat thromboxane synthase gene transcription by peroxisome proliferator-activated receptor γ in macrophages via an interaction with NRF2
Y Ikeda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
H2O2 sensing through oxidation of the Yap1 transcription factor
A Delaunay et al.
EMBO JOURNAL (2000)
A family of drug transporters: The multidrug resistance-associated proteins
P Borst et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2000)
Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells
YS Zhang
CARCINOGENESIS (2000)
Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages
T Ishii et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element
H Hoshino et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Inhibition of the 26S proteasome induces expression of GLCLC, the catalytic subunit for γ-glutamylcysteine synthetase
KR Sekhar et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Thioredoxin reductase
D Mustacich et al.
BIOCHEMICAL JOURNAL (2000)
p38 mitogen-activated protein kinase negatively regulates the induction of phase II drug-metabolizing enzymes that detoxify carcinogens
R Yu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
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