期刊
TETRAHEDRON
卷 59, 期 31, 页码 5831-5836出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(03)00985-2
关键词
lithiation; electrophilic cyanation; phenyl cyanate; cyano arenes
A one-pot procedure for the conversion of mono-substituted arenes and heteroarenes into the ortho-cyano derivatives was achieved through directed lithiation followed by electrophilic cyanation with phenyl cyanate. This reaction method proved to be applicable to halogen-lithium exchanged intermediates, so especially useful for the synthesis of benzonitriles. The scope of the reaction sequence was explored using a number of substrates. (C) 2003 Elsevier Ltd. All rights reserved.
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