Biosynthetic studies of versipelostatin, a novel 17-membered α-tetronic acid involved macrocyclic compound isolated from Streptomyces versipellis

Versipelostatin, a novel microbial metabolite consisting of a 17-membered macrocyclic aglycone with an alpha-acyltetronic acid functional group and sugar moieties was shown to be biosynthesized through a polyketide intermediate and the involvement of glyceric acid. (C) 2003 Elsevier Ltd. All rights reserved.