期刊
CANCER LETTERS
卷 198, 期 1, 页码 37-42出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3835(03)00285-4
关键词
cancer chemoprevention; mogroside V; 11-oxo-mogroside V; Momordica grosvenori; peroxynitrite; anti-tumor-initiator
类别
To search for cancer chemopreventive agents from natural resources, many phytochemicals and food additives have been screened. Consequently, two natural sweeteners, mogroside V and 11-oxo-mogroside V isolated from the fruits of Momordica grosvenori, exhibited strong inhibitory effect on the primary screening test indicated by the induction of Epstein-Barr virus early antigen (EBV-EA) by a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). These sweet glycosides, having cucurbitane triterpenoid aglycon, exhibited the significant inhibitory effects on the two-stage carcinogenesis test of mouse skin tumors induced by peroxynitrite (ONOO-) as an initiator and TPA as a promoter. Further, 11-oxo-mogroside V also exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin tumor induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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