期刊
ARCHIVES OF TOXICOLOGY
卷 83, 期 3, 页码 281-285出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00204-008-0364-0
关键词
Endocrine disruptor; Bisphenol A; Breast cancer; Biomonitoring
类别
资金
- KOSEF
The incidence of breast cancer in Korea has been increasing for the last two decades (1983-2005), and now, breast cancer is ranked the leading cause of cancer in Korean women. Along with other endocrine disrupting chemicals (EDCs), bisphenol A (BPA) has been suspected as a potential risk factor for breast cancer. We studied potential associations between BPA exposure and breast cancer risks in Korean women by performing biomonitoring of BPA among breast cancer patients and controls (N = 167). Blood samples were collected between 1994 and 1997 and kept over 10 years in a freezer under well controlled conditions. The blood BPA levels determined by HPLC/FD, ranged between LOD (0.012 A mu g/L) and 13.87 A mu g/L (mean +/- A SD, 1.69 +/- A 2.57 A mu g/L; median, 0.043 A mu g/L). In age-matched subjects (N = 152), there were some associations between BPA levels and risks of breast cancer, such as age at first birth and null parity. However, there were no significant differences in blood BPA levels between the cases and the controls (P = 0.42). Considering interactions between BPA exposure and risks of breast cancer, we suggest further enlarged biomonitoring studies of BPA to provide effective prevention against breast cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据