期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 205, 期 1-2, 页码 159-168出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0303-7207(03)00090-X
关键词
signal transduction; prothoracicotropic hormone (insect) steroidogenesis; cAMP; extracellular-signal regulated kinase (ERK) calcium
资金
- NIGMS NIH HHS [GM63198-01] Funding Source: Medline
The synthesis of ecdysteroids by the lepidopteran prothoracic gland is regulated by a brain neuropeptide hormone, prothoracicotropic hormone (PTTH). In Manduca sexta glands, PTTH stimulates several events including Ca2+ influx, Ca2+-dependent cAMP generation and the activation of several protein kinases. In the present study, the path by which PTTH stimulates extracellular signal-activated regulated kinase (ERK) phosphorylation was investigated using PTTH and second messenger analogs. The results indicate that Ca2+-dependent processes, other than cAMP generation, play the major role in PTTH stimulation of ER K phosphorylation in larval prothoracic glands, that cAMP-dependent events increase in importance during later development and that PTTH-stimulated ERK phosphorylation is highest in larval glands. The decline in PTTH-stimulated ERK phosphorylation associated with metamorphosis results from decreased ERK levels and an increased basal rate of ERK phosphorylation. The data suggest that the role or importance of components of the PTTH signal transduction cascade are not fixed and can change during development. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
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