期刊
SEMINARS IN CANCER BIOLOGY
卷 13, 期 4, 页码 283-292出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/S1044-579X(03)00042-7
关键词
antisense oligonucleotides; fusion genes in leukemia and lymphoma; gene silencing
类别
Leukemias and lymphomas are often characterized by non-random chromosomal translocations that, at the molecular level, induce the activation of specific oncogenes or create novel chimeric genes. They have frequently been regarded as optimal targets for gene-silencing approaches because of the large body of evidence that these single abnormalities directly initiate and maintain the malignant process. Herein, we discuss RNA interference (RNAi)-based approaches for targeting the fusion sites of chromosomal translocations as a future treatment option in leukemias and lymphomas. (C) 2003 Elsevier Ltd. All rights reserved.
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