期刊
EUROPEAN JOURNAL OF CANCER
卷 39, 期 12, 页码 1654-1667出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0959-8049(03)00203-X
关键词
sentinel lymph nodes; breast cancer; micrometastasis; isolated tumour cell; occult metastasis; survival; non-sentinel node metastasis; frozen section; intraoperative cytology; molecular analysis
类别
Controversies and inconsistencies regarding the pathological work-LIP of sentinel lymph nodes (SNs) led the European Working Group for Breast Screening Pathology (EWGBSP) to review published data and current evidence that can promote the formulation of European guidelines for the pathological work-up of SNs. After an evaluation of the accuracy of SN biopsy as a staging procedure, the yields of different sectioning methods and the immunohistochemical detection of metastatic cells are reviewed. Currently published data do not allow the significance of micrometastases or isolated tumour cells to be established, but it is suggested that approximately 18% of the cases may be associated with further nodal (non-SN) metastases, i.e. approximately 2% of all patients initially staged by SN biopsy. The methods for the intraoperative and molecular assessment of SNs are also surveyed. (C) 2003 Elsevier Ltd. All rights reserved.
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