期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 7, 期 4, 页码 469-475出版社
ELSEVIER SCI LTD
DOI: 10.1016/S1367-5931(03)00079-6
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资金
- NIDA NIH HHS [DA15197, DA13173, R01 DA015197-01, R01 DA013173-03, R01 DA015197] Funding Source: Medline
The medicinal properties of exogenous cannabinoids have been recognized for centuries and can largely be attributed to the activation in the nervous system of a single G-protein-coupled receptor, CB1. However, the beneficial properties of cannabinoids, which include relief of pain and spasticity, are counterbalanced by adverse effects such as cognitive and motor dysfunction. The recent discoveries of anandamide, a natural lipid ligand for CB1, and an enzyme, fatty acid amide hydrolase (FAAH), that terminates anandamide signaling have inspired pharmacological strategies to augment endogenous cannabinoid ('endocannabinoid') activity with FAAH inhibitors, which might exhibit superior selectivity in their elicited behavioral effects compared with direct CB1 agonists.
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