期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 31, 期 -, 页码 889-892出版社
PORTLAND PRESS
DOI: 10.1042/bst0310889
关键词
dystrophin; gephyrin; postsynaptic mechanism; presynaptic mechanism; synapse; type A gamma-aminobutyric acid receptor (GABA(A) receptor)
Postsynaptic clustering of GABA(A) (type A gamma-aminobutyric acid) receptors is essential to ensure proper function of GABAergic synapses. This process is initiated during synapse formation and is maintained throughout life. The tubulin-associated protein gephyrin is required for clustering of GABA(A) receptors, but its specific role in this process is not understood. A second protein associated selectively with GABA(A) receptors at postsynaptic sites is dystrophin. it is present in a subset of GABAergic synapses along with several partners, forming the dystrophin-associated protein complex. In this review, we discuss recent advances in the role of neuronal activity and trans-synaptic signaling for the clustering of gephyrin and dystrophin during synaptogenesis and on the role of these proteins for plasticity and maintenance of mature synapses.
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