期刊
CURRENT MEDICINAL CHEMISTRY
卷 10, 期 16, 页码 1527-1533出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867033457214
关键词
mitochondria; apoptosis; VDAC; heart; cytochrome c; cell death; Bcl-2; Bax
资金
- NHLBI NIH HHS [HL-60590, HL-61518] Funding Source: Medline
Voltage-dependent anion channels (VDAC) are major constituents of the outer mitochondrial membrane. Over the past few years, several hypotheses and mechanisms have been forwarded for and against a role for VDAC in outer mitochondrial membrane permeability and the subsequent release of apoptosis promoting factors. The current review outlines current knowledge related to the role of VDAC in the regulation of cell death and speculates on possible therapeutic applications through VDAC modulation.
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