期刊
BIOLOGY OF REPRODUCTION
卷 69, 期 2, 页码 430-436出版社
SOC STUDY REPRODUCTION
DOI: 10.1095/biolreprod.103.016147
关键词
assisted reproductive technology; developmental biology; embryo; gene regulation
资金
- NHLBI NIH HHS [R01 HL051587-12, R01 HL051587, HL51587] Funding Source: Medline
Cloning by somatic cell nuclear transfer can result in the birth of animals with phenotypic and gene expression abnormalities. We compared adult cloned pigs and adult pigs from naturally bred control females using a series of physiological and genetic parameters, including detailed methylation profiles of selected genomic regions. Phenotypic and genetic analyses indicated that there are two classes of traits, one in which the cloned pigs have less variation than controls and another characterized by variation that is equally high in cloned and control pigs. Although cloning creates animals within the normal phenotypic range, it increases the variability associated with some traits. This finding is contrary to the expectation that cloning can be used to reduce the size of groups involved in animal experimentation and to reproduce an animal, including a pet, with a homogenous set of desired traits.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据