期刊
JOURNAL OF NEUROCHEMISTRY
卷 86, 期 3, 页码 582-590出版社
WILEY-BLACKWELL
DOI: 10.1046/j.1471-4159.2003.01879.x
关键词
aggregation; Alzheimer's disease; non-mutant tau; phosphorylation; transgenic
资金
- NIA NIH HHS [R01 AG022102] Funding Source: Medline
- NIMH NIH HHS [MH 38623] Funding Source: Medline
- NINDS NIH HHS [NS 07098] Funding Source: Medline
Neurofibrillary tangles are composed of insoluble aggregates of the microtubule-associated protein tau. In Alzheimer's disease the accumulation of neurofibrillary tangles occurs in the absence of tau mutations. Here we present mice that develop pathology from non-mutant human tau, in the absence of other exogenous factors, including beta-amyloid. The pathology in these mice is Alzheimer-like, with hyperphosphorylated tau accumulating as aggregated paired helical filaments. This pathologic tau accumulates in the cell bodies and dendrites of neurons in a spatiotemporally relevant distribution.
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