期刊
CURRENT OPINION IN IMMUNOLOGY
卷 15, 期 4, 页码 378-384出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/S0952-7915(03)00066-9
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资金
- NCI NIH HHS [P50 CA86306, R01 CA84572] Funding Source: Medline
Positron emission tomography (PET) has been used clinically to measure enzyme reactions, ligand-receptor interactions, cellular metabolism and cell proliferation. Until recently, however, PET has not been suitable for small animal models because of resolution limitations. Development of micro-PET instrumentation for small animal imaging and the availability of positron-emitting tracers has made this technology accessible for the non-invasive, quantitative and repetitive imaging of biological function in living animals. The development of new probes and positron-imaging based reporter genes has extended micro-PET applications to investigations of metabolism, enzyme activity, receptor-ligand interactions, protein-protein interactions, gene expression, adoptive cell therapy and somatic gene therapy. Because small animal PET is immediately extrapolatable to the clinic, laboratory advances should rapidly be translated to clinical practice.
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