期刊
DEVELOPMENTAL CELL
卷 5, 期 2, 页码 351-358出版社
CELL PRESS
DOI: 10.1016/S1534-5807(03)00227-2
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资金
- NCI NIH HHS [P30-CA14051, P01-CA42063] Funding Source: Medline
- NIGMS NIH HHS [T32-GM07748, R37-GM34277] Funding Source: Medline
We have identified microRNAs (miRNAs) in undifferentiated and differentiated mouse embryonic stem (ES) cells. Some of these appear to be ES cell specific, have related sequences, and are encoded by genomic loci clustered within 2.2 kb of each other. Their expression is repressed as ES cells differentiate into embryoid bodies and is undetectable in adult mouse organs. In contrast, the levels of many previously described miRNAs remain constant or increase upon differentiation. Our results suggest that miRNAs may have a role in the maintenance of the pluripotent cell state and in the regulation of early mammalian development.
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