期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 136, 期 2, 页码 145-149出版社
SPRINGER
DOI: 10.1023/A:1026310722105
关键词
bumetanide; Na+,K+,2Cl(-) cotransport; biologically active substances; smooth muscle cells
The effect of Na+,K+,2Cl(-) cotransport inhibitor bumetanide on action potentials and contractions of smooth muscle cells in the ureter of guinea pigs evoked by electrical stimulation was studied by the method of double sucrose bridge. Bumetanide (10-100 muM) dose-dependently suppressed action potential and contractions of smooth muscle cells induced by 1-10 muM histamine, 10 muM mesatone, 5 mM tetraethylammonium, and 100 muM sodium nitroprusside. Our findings suggest that test substances modulate Na+,K+,2Cl(-) cotransport in smooth muscle cells.
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