期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 31, 期 -, 页码 857-860出版社
PORTLAND PRESS
DOI: 10.1042/BST0310857
关键词
adaptor protein-2 (AP-2); clathrin-coated vesicle; clathrin-mediated endocytosis; kinase; phosphorylation
The process of clathrin-coated vesicle (CCV) formation/disassembly has been studied intensively, and numerous proteins have been identified which aid this process. We have learnt a great deal about individual components of the CCV machinery, and now the ultimate aim is to elucidate the mechanisms regulating clathrin-mediated trafficking. one of the fundamental processes governing the complicated network of interactions is phosphorylation. it has been known for some time that several proteins associated with clathrin-coated vesicles are substrates for protein kinases. These proteins include clathrin, three of the four adaptor complex subunits, dynamin 1, synaptojanin 1 and the amphiphysins. However, the identities of the kinases involved in this process remained largely unknown until recently. This short review discusses advances in our knowledge of how CCV formation/disassembly is regulated by the phosphorylation/dephosphorylation cycle and the role played by specific protein kinases in that process.
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