期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 26, 期 8, 页码 597-600出版社
PHARMACEUTICAL SOCIETY KOREA
DOI: 10.1007/BF02976707
关键词
silybin; gram-positive bacteria; 1,6-diphenyl-1,3,5-hextriene (DPH)
Silybin has a potent antibacterial activity, more potent than silymarin II, against gram-positive bacteria without hemolytic activity, whereas it has no antimicrobial activity against gram-negative bacteria or fungi. The mode of action of silybin against the gram-positive bacterial cell was examined by investigating the change in plasma membrane dynamics of bacterial cells using 1,6-diphenyl-1,3,5-hextriene (DPH) as a membrane probe and by assessing the inhibition of macromolecular synthesis using radiolabeled incorporation assay. The results showed that silybin inhibited RNA and protein synthesis on gram-positive bacteria.
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