期刊
NATURE REVIEWS CANCER
卷 3, 期 8, 页码 601-614出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc1144
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Recent findings have indicated that dietary calcium, vitamin D and folate can modulate and inhibit colon carcinogenesis. Supporting evidence has been obtained from a wide variety of preclinical experimental studies, epidemiological findings and a few human clinical trials. Important molecular events and cellular actions of these micronutrients that contribute to their tumour-modulating effects are discussed. They include a complex series of signalling events that affect the structural and functional organization of colon cells.
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