Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines

We examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin showed complete inhibition at 10 muM through the induction of apoptosis.