Evidence for an antihyperalgesic effect of venlafaxine in vincristine-induced neuropathy in rat

Venlafaxine, a new antidepressant with fewer side effects, could be of interest to reduce neuropathic pain following antineoplasic drug treatment. In the present study, we demonstrated that venlafaxine inhibits hyperalgesia in a new rat model of neuropathy induced by the antineoplasic drug vincristine, and exerts its effect preferentially via supraspinal and spinal mechanisms. (C) 2003 Elsevier B.V. All rights reserved.