期刊
SEMINARS IN CANCER BIOLOGY
卷 13, 期 4, 页码 253-258出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/S1044-579X(03)00038-5
关键词
microRNA; miRNA; cancer; oncogenesis; RNAi; notch; bHLH; Bic; His-1; mir-155; mir-142; mir-15; mir-16
类别
The general basis of cancer is the loss of cell identity and inappropriate proliferation of cells. Classically, a universal paradigm in oncogenesis is the accumulation of mutations in the open reading frames of protein-encoding oncogenes and tumor suppressors. The identification of new classes of noncoding RNAs (ncRNA) important for development and cell homeostasis will likely change this current paradigm. Recent data suggests that a special class of ncRNAs called microRNAs might be involved in human disease. This review proposes a role for microRNAs in oncogenesis. (C) 2003 Published by Elsevier Science Ltd.
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