期刊
GENE EXPRESSION PATTERNS
卷 3, 期 4, 页码 427-430出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S1567-133X(03)00081-4
关键词
taste bud; tongue; sonic hedgehog; Mash1; Prox1; Nkx2.2; homeobox gene
In mammals, taste buds are maintained by continuous turnover of cells, even in adulthood. Cell proliferation and differentiation continue to produce taste cells, which express various genes related to taste reception. We found the co-expression of Sonic hedgehog (Shh) with Prox1 and that of Nkx2.2 with Mash1 in adult mouse taste buds. Whereas Prox1 was expressed strongly in cells in the basal region of mouse taste buds where Shh was co-expressed, it was expressed weakly in almost all taste bud cells lacking Shh expression. At 0.5 day after birth, when taste cells have not yet differentiated, the expressions of Shh and Prox1 completely overlapped in the epithelium of circumvallate papillae. Nkx2.2 was observed in cells expressing Mash1, but not in cells expressing genes related to taste reception, such as gustducin and TIR3. Almost all fusiform cells expressing Mash1 co-expressed Nkx2.2, while the majority of round cells expressing Mash l in the basal region of taste buds lacked Nkx2.2 expression. (C) 2003 Elsevier Science B.V. All rights reserved.
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