期刊
AUTOIMMUNITY
卷 36, 期 6-7, 页码 323-330出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/08916930310001604207
关键词
apoptosis; autoimmune disorders; tumor necrosis factor receptor; BCL-2; family; death receptors
类别
资金
- NIAID NIH HHS [AI01821] Funding Source: Medline
- NIDDK NIH HHS [DK47417, DK44972, DK57938] Funding Source: Medline
Apoptosis or programmed cell death plays a central role in regulating not only the development of lymphocytes but also in their homeostasis. A breakdown in apoptosis related signaling mechanisms could result in the development of autoimmune disorders. The past decade has witnessed an explosive increase in knowledge with respect to various apoptotic signaling pathways and their aberrant behavior in autoimmune disorders. Although Fas/FasL mediated signaling appears to be a common paradigm that has emerged from studies in various autoimmune disorders, examples suggesting a role for other cell death pathways have also surfaced. Understanding the definitive role of apoptosis in various autoimmune disorders is likely to define novel targets for future therapeutic intervention.
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