期刊
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
卷 94, 期 6, 页码 1062-1073出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.apmr.2013.01.013
关键词
Lower extremity; Neoplasms; Rehabilitation; Sarcoma; Survivors; Upper extremity
资金
- NCI NIH HHS [U24 CA055727] Funding Source: Medline
Objective: To evaluate health status and participation restrictions in survivors of childhood extremity sarcomas. Design: Members of the Childhood Cancer Survivor Study cohort with extremity sarcomas who completed questionnaires in 1995, 2003, or 2007 were included. Setting: Cohort study of survivors of extremity sarcomas. Participants: Childhood extremity sarcoma survivors (N=1094; median age at diagnosis, 13y (range, 0-20y); current age, 33y (range, 10-53y); 49% male; 87.5% white; 75% had lower extremity tumors) who received their diagnosis and treatment between 1970 and 1986. Interventions: Not applicable. Main Outcome Measures: Prevalence rates for poor health status in 6 domains and 5 suboptimal social participation categories were compared by tumor location and treatment exposure with generalized estimating equations adjusted for demographic/personal factors and time/age. Results: In adjusted models, when compared with upper extremity survivors, lower extremity survivors had an increased risk of activity limitations but a lower risk of not completing college. Compared with those who did not have surgery, those with limb-sparing (LS) and upper extremity amputations (UEAs) were 1.6 times more likely to report functional impairment, while those with an above-the-knee amputation (AKA) were 1.9 times more likely to report functional impairment. Survivors treated with LS were 1.5 times more likely to report activity limitations. Survivors undergoing LS were more likely to report inactivity, incomes <$20,000, unemployment, and no college degree. Those with UEAs more likely reported inactivity, unmarried status, and no college degree. Those with AKA more likely reported no college degree. Treatment with abdominal irradiation was associated with an increased risk of poor mental health, functional impairment, and activity limitation. Conclusions: Treatment of lower extremity sarcomas is associated with a 50% increased risk for activity limitations; upper extremity survivors are at a 10% higher risk for not completing college. The type of local control influences health status and participation restrictions. Both of these outcomes decline with age. (C) 2013 by the American Congress of Rehabilitation Medicine
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