期刊
INTENSIVE CARE MEDICINE
卷 29, 期 8, 页码 1380-1383出版社
SPRINGER
DOI: 10.1007/s00134-003-1833-9
关键词
burn; oxidative stress; superoxide dismutase; lipid peroxidation; protein carbonyl; xanthine oxidase
Objective.; To determine xanthine oxidase and superoxide dismutase activities, lipid peroxidation, protein carbonylation, and total radical-trapping antioxidant parameter in survivors and nonsurvivors patients with severe burn injury. Design and setting: Prospective, comparative observational study in an intensive care unit, burn division, in a trauma hospital. Patients: Twenty-five consecutive patients who met the established criteria for severe burn injury (total burn surface area of more than 30%). Measurements and results: Plasma thiobarbituric acid reactive species and protein carbonyls levels were significantly higher in nonsurvivors than in survivors at 0 and 6 h. Elevated xanthine oxidase activity at 0 h was associated with adverse outcome after burn injury. In contrast, plasma superoxide dismutase activity and total radical-trapping antioxidant parameter did not differ significantly between nonsurvivors and survivors at any time point. Conclusions: For the first time we demonstrate the value of oxidative parameters, namely thiobarbituric acid reactive species, protein carbonyls, and xanthine oxidase activity, in identifying burn patients with a poor prognosis. Whether these parameters are merely markers of clinical course, or whether they signal specific deleterious effects of oxidative stress during the burn injury remains to be elucidated.
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