期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 31, 期 -, 页码 806-809出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0310806
关键词
bactericidal/permeability-increasing protein (BPI); gene expression; gene structure; host defence; innate immunity; lipopolysaccharide-binding protein (LBP); palate, lung and nasal epithelium clone (PLUNC)
PLUNC (palate, lung and nasal epithelium clone) is a small, secreted protein that is expressed in the oropharynx and upper airways of humans, mice and fats. We have described a family of at least 14 PLUNC genes localized on chromosome 20 (in humans), 2 (in mice) or 3 (in rats). These rapidly evolving proteins are structurally related to lipopolysaccharide-binding protein (LBP) and bactericidal/permeability-increasing protein (BPI). In the present analysis we comment on the comparative aspects of this protein family, which may function to protect epithelial surfaces from pathogenic micro-organisms.
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