期刊
JOURNAL OF BACTERIOLOGY
卷 185, 期 16, 页码 5007-5011出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.185.16.5007-5011.2003
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资金
- NIAID NIH HHS [AI22223] Funding Source: Medline
Site-directed mutagenesis was employed to create lesions in fimI, a gene of uncertain function located in the chromosomal gene cluster (fim) involved in Escherichia coli type 1 pilus biosynthesis. Chromosomal fimI mutations produced a piliation-negative phenotype. Complementation analysis indicated that a fimI'-kan insertion mutation and a fimI frameshift mutation produced polarity-like effects not seen with an in-frame fimI deletion mutation. Minicell analysis associated fimI with a 16.4-kDa noncytoplasmic protein product (FimI). We conclude that FimI has a required role in normal pilus biosynthesis.
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