期刊
MOLECULAR AND CELLULAR BIOLOGY
卷 23, 期 15, 页码 5293-5300出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.23.15.5293-5300.2003
关键词
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资金
- NCI NIH HHS [R01 CA025951, CA 25951] Funding Source: Medline
- NIEHS NIH HHS [R01 ES008823, ES 08823] Funding Source: Medline
Early nutrition affects adult metabolism in humans and other mammals, potentially via persistent alterations in DNA methylation. With viable yellow agouti (A(vy)) mice, which harbor a transposable element in the agouti gene, we tested the hypothesis that the metastable methylation status of specific transposable element insertion sites renders them epigenetically labile to early methyl donor nutrition. Our results show that dietary methyl supplementation of ala dams with extra folic acid, vitamin B-12, choline, and betaine alter the phenotype of their A(vy)/a offspring via increased CpG methylation at the A(vy) locus and that the epigenetic metastability which confers this lability is due to the A(vy) transposable element. These findings suggest that dietary supplementation, long presumed to be purely beneficial, may have unintended deleterious influences on the establishment of epigenetic gene regulation in humans.
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