期刊
NEUROTOXICOLOGY
卷 24, 期 4-5, 页码 741-745出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0161-813X(03)00025-1
关键词
blood-brain barrier; rat brain endothelial; central nervous system; astrocytes; chlorpyrifos
资金
- NIEHS NIH HHS [ES 010563, ES 07331] Funding Source: Medline
The mammalian central nervous system (CNS) is characterized by the blood-brain barrier (BBB), a restrictive barrier endowed with the maintenance of homeostatic control of an optimal milieu within the brain. Whereas in tissues other than the CNS, concentrations of various metabolites (amino acids, K+) can undergo frequent fluctuations, the CNS must keep rigorous control over the extracellular cerebral fluid composition, preventing the mirroring of transient fluctuations in blood, because abrupt changes in these metabolites can translate to aberrant CNS function. The BBB is a specialized structure accomplished by individual endothelial cells that are continuously linked by tight junctions. This brief review will address pertinent issues to development of the BBB. Particular emphasis will be directed at the role of astrocytes in the induction and maintenance of the restrictive properties of this barrier, and the utility of in vitro culture models in surveying transport kinetics, exemplified by recent studies with the pesticide, chlorpyrifos. (C) 2003 Elsevier Science Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据