期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 141, 期 1-2, 页码 65-73出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(03)00223-6
关键词
astrocytes; microglia; inflammation; glial limiting membrane
We analyzed expression of osteopontin (OPN), a cytokine regulating tissue repair and inflammation, in astrocytes and microglia in response to systemic lipopolysaccharide (LPS) administration (250 mug/100 g). OPN mRNA expression appeared in subpial astrocytes as early as 6 h, and then spread over the brain parenchyma. The signal for OPN mRNA reached a peak at 24 It post-injection, and returned to basal levels after 48 h. Changes in OPN immunoreactivity in the LPS-injected rat mirrored OPN mRNA induction patterns. These results provide the first evidence of OPN induction in astrocytes and microglia following peripheral immune challenge, and suggest that OPN may play a key role in the pathogenesis of neuroinflammation. (C) 2003 Elsevier B.V All rights reserved.
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