Novel coumarin derivatives of heterocyclic compounds as lipid-lowering agents

Coumarin derivatives of different heterocycles (5,7a-i, 10 and 11) were designed based on cyclisation of 2-ethoxy-3phenylpropanoic acid and 2-benzylmalonic acid as novel lipid-lowering agents and their preliminary in vivo screening indicates 7c has moderate triglyceride-lowering activity. (C) 2003 Elsevier Ltd. All rights reserved.