期刊
CELL
卷 114, 期 3, 页码 323-334出版社
CELL PRESS
DOI: 10.1016/S0092-8674(03)00570-1
关键词
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资金
- NCI NIH HHS [R01-CA61253, P01-CA80111, F32-CA79197, CA88843, R01-CA65842] Funding Source: Medline
Here we describe how patterns of gene expression in human tumors have been deconvoluted to reveal a mechanism of action for the cyclin D1 oncogene. Computational analysis of the expression patterns of thousands of genes across hundreds of tumor specimens suggested that a transcription factor, C/EBPbeta/Nf-II6, participates in the consequences of cyclin Di overexpression. Functional analyses confirmed the involvement of C/EBPbeta in the regulation of genes affected by cyclin D1 and established this protein as an indispensable effector of a potentially important facet of cyclin D1 biology. This work demonstrates that tumor gene expression databases can be used to study the function of a human oncogene in situ.
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